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Positive Selection of Tyrosine Loss in Metazoan Evolution - Take Two

Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

It was suggested that GC content variation can largely explain the observed tyrosine frequency variation independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

Signaling NoiseFor further information see Tan et al. Science May 20th 2011.

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