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Digital ‘Rosetta Stone’ Decrypts How Mutations Rewire Cancer Cells
Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
Quantitative bioinformatics studies utilizing genomics, proteomics and imaging experiments require the integration of vast amounts of data in order to gain new insights from large population data sets. In an effort to solve some of life science’s most complex questions, The Linding Laboratory in Denmark partnered with HPE/SGI to further its research at the Biotech Research and Innovation Centre (BRIC), University of Copenhagen and extract deeper insights into areas such as cell and cancer biology using high performance computing (HPC).
Located in Press
Personalized network-based treatments in oncology.
Clin Pharmacol Ther. 2013 Dec;94(6):646-50.
Located in Publications / Linding Lab, BRIC & DTU [2011-present]
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling.
Cell. 2015 Sep 16. pii: S0092-8674(15)01108-3. doi: 10.1016/j.cell.2015.08.056.
Located in Publications / Linding Lab, BRIC & DTU [2011-present]
Unmasking Determinants of Specificity in the Human Kinome.
Cell. 2015 Sep 16. pii: S0092-8674(15)01109-5. doi: 10.1016/j.cell.2015.08.057.
Located in Publications / Linding Lab, BRIC & DTU [2011-present]
Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
Cell Reports 2017 Sep 19;20(12):2784-2791. doi: 10.1016/j.celrep.2017.08.095.
Located in Publications / Linding Lab, BRIC & DTU [2011-present]